With the College of Medicine’s newly expanded cryo-electron microscopy (cryo-EM) facility, in all probability probably the most trendy microscope experience is now accessible for use.
The Titan Krios (Thermo Fisher) is a state-of-the-art cryo-transmission electron microscope that is completely outfitted for high-throughput information assortment of the utmost top quality attainable. It has the facility to seek out out the atomic development of a single protein or view molecules interacting of their cell context. With expertise in every single particle analysis and cryo-electron tomography, school directors Matt Swulius, PhD, assistant professor of biochemistry and molecular biology, and Kenneth Lee, PhD, assistant professor of cell and molecular physiology, may be discovered to supply guidance, teaching or information assortment for researchers on the College of Medicine.
“Cryo-EM is a crucial helpful useful resource for cell and structural biologists alike,” Swulius acknowledged. “This addition to our EM arsenal will allow researchers to capitalize on this new experience, whereas providing modern cryo-EM teaching for early-career scientists and school college students.”
A neuroscientist by teaching, Swulius is using cryo-electron tomography to assessment the development of neuronal branches rising in custom and to raised understand the cell processes of neurological enchancment and sickness.
“Determining atomic constructions of natural molecules using X-ray crystallography requires well-ordered crystals, and that’s sometimes a monumental downside for membrane proteins,” Lee acknowledged. “The one particles analysis methodology sidesteps the need to obtain crystals and presents us entry to high-resolution structural information of membrane proteins, a number of which are clinically important drug targets. Our state-of-the-art cryo-EM facility presents the utilized sciences that make this attainable.”
Lee is a structural biologist who makes use of single-particle cryo-EM as a tool to dissect the mechanisms of membrane proteins involved in important fundamental natural processes and diseases, along with energy ache and neurodegenerative issues.
Faculty, employees and school college students contemplating learning further about cryo-EM and the way in which it could be utilized of their laboratories’ initiatives should contact school co-directors Swulius or Lee at [email protected] or [email protected], respectively.
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- Uncover evaluation at Penn State College of Medicine
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- See an inventory of NIH and completely different grants obtained by the college
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